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Table 4 Enriched Gene Ontology terms and KEGG pathway identified for proteins with reduced expression in C-AME (< 0.5-fold) compared to F-AME

From: A cellular and proteomic approach to assess proteins extracted from cryopreserved human amnion in the cultivation of corneal stromal keratocytes for stromal cell therapy

  Enrichment scores Biological pathways Proteins (UniProt Accession no.) p
(A) Enriched GO terms (DAVID)
 1 15.19 GO:0098609~cell-cell adhesion P07355, P62820, Q8WUF5, P61026, P31947, P06733, P04075, Q9H444, P43487, Q9C0C2, P30041, Q15056, P46109, P31949, Q15907, Q99497, Q9UJU6, O60437, P00338, Q92817, P31939, Q16643, P20810, Q9NYL9, P0DMV9, Q16658, P63244, Q14847, Q8NC51, Q14247 1.3E-12*
 2 6.45 GO:0043488~regulation of mRNA stability P27695, P25788, P25789, P25786, P0DMV9, P20618, P28070, O14818, Q92945, P60900, P49721, P04792, P49720, Q8NC51, P28066 2E-6*
 3 6.45 GO:0051603~proteolysis involved in cellular protein catabolic process P20618, P25788, P25789, P25786, P28070, O14818, P07858, P60900, P49721, P49720 1E-4*
 3 4.23 GO:0006096~glycolytic process P60174, P04406, P00558, P04075, P00338, P06733, P06744 0.026*
(B) KEGG pathways (DAVID)
 1 6.45 hsa03050:Proteasome P20618, P25788, P25789, P25786, P28070, O14818, P60900, P49721, P49720, P28066 3.6E-4*
 2 4.23 hsa01130:Biosynthesis of antibiotics P40925, P60174, P04406, P37837, P06733, P00338, P04075, Q03154, P06744, P31939, P11766, P54687, P29401, P14324, P00558, P14550, P21399 0.014*
  1. GO = gene ontology, KEGG = kyoto encyclopedia of genes and genomes, F-AME = fresh human amnion extract, C-AME = cryopreserved human amnion extract, DAVID = database for annotation, visualization and integrated discovery
  2. The biological events were ranked using enrichment scores. *Adjusted Benjamini p < 0.05 represents statistical significance
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Eye and Vision

ISSN: 2326-0254